The effect of valerian on the anxiety and depression symptoms of the menopause in women referred to shahrekord medical centers

Background: Anxiety and depression as the most common psychological disorders are associated with gynecologic problems. Women, especially in this age usually increasingly tend to be treated with some herbal compounds and nutritional supplements. Objective: The present study aims to determine the effect of Valerian on anxiety and depressive symptoms in menopausal women referred to Shahrekord medical centers. Methods: This double-blind clinical trial study was carried out on women referred to Shahrekord medical center. In present study, 48 eligible women aged 45 to 62 years have been divided randomly into two groups (29 in Valerian and 19 in placebo). The information was completed via demographic questionnaire, Hamilton anxiety rating scale, and Beck depression inventory before and 2 months after treatment. The data were analyzed by the Mann-Whitney Tests and Wilcoxon tests using SPSS 11.5 software. Results: According to the findings of the present study, both groups were match regarding to depression and anxiety levels at the first stages of the study (P> 0.05). After the intervention, anxiety level and depressive symptoms were decreased significantly in valerian group (P=0.001). Conclusion: The results have shown that Valerian is effective in the treatment of anxiety and depression in menopausal women and could be considered as an alternative treatment

Cluster Index Modulation for Reconfigurable Intelligent Surface-Assisted mmWave Massive MIMO

In this paper, we propose a transmission mechanism for a reconfigurable intelligent surface (RIS)-assisted millimeter wave (mmWave) system based on cluster index modulation (CIM), named best-gain optimized cluster selection CIM (BGCS-CIM). The proposed BGCS-CIM scheme considers effective cluster power gain and spatial diversity gain obtained by the additional paths within the indexed cluster to construct an efficient codebook. We also integrate the proposed scheme into a practical system model to create a virtual path between transmitter and receiver where the direct link has been blocked. Thanks to the designed whitening filter, a closed-form expression for the upper bound on the average bit error rate (ABER) is derived and used to validate the simulation results. It has been shown that the proposed BGCS-CIM scheme outperforms the existing benchmarks thanks to its higher effective cluster gain, spatial diversity of indexed clusters, and lower inter-cluster interference.Comment: Submitted in IEE

The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model

Background. The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cisplatin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice. Materials and methods. Tumors of an average volume of 630 mm3 were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates. Results. As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy. Conclusions. The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses

Qualitative evaluation of filter function in brain SPECT [Persian]

Abstract Introduction: Filtering can greatly affect the quality of clinical images. Determining the best filter and the proper degree of smoothing can help to ensure the most accurate diagnosis. Methods: Forty five patient's data aquired during brain phantom SPECT studies were reconstructed using filtered back-projection technique. The ramp, Shepp-Logan, Cosine, Hamming, Hanning, Butterworth, Metz and Wiener filters were examined to find the optimum condition for each filter. For each slice image, 6200 reconstruction options were ..

Kdr genotyping and the first report of V410L and V1016I kdr mutations in voltage-gated sodium channel gene in Aedes aegypti (Diptera: Culicidae) from Iran

Background: Aedes aegypti is the main vector of arboviral diseases worldwide. The species invaded and became established in southern Iran in 2020. Insecticide-based interventions are primarily used for its control. With insecticide resistance widespread, knowledge of resistance mechanisms is vital for informed deployment of insecticidal interventions, but information from Iranian Ae. aegypti is lacking. Methods: Fifty-six Ae. aegypti specimens were collected from the port city of Bandar Lengeh in Hormozgan Province in the South of Iran in 2020 and screened for kdr mutations. The most common kdr mutations in Latin America and Asia (V410L, S989P, V1016G/I and F1534C), especially when present in combinations, are highly predictive of DDT and pyrethroid resistance were detected. Phylogenetic analyses based on the diversity of S989P and V1016G/I mutations were undertaken to assess the phylogeography of these kdr mutations. Results: Genotyping all four kdr positions of V410L, S989P, V1016G/I and F1534C revealed that only 16 out of the 56 (28.57%) specimens were homozygous wild type for all kdr mutation sites. Six haplotypes including VSVF (0.537), VSVC (0.107), LSVF (0.016), LSIF (0.071), VPGC (0.257) and LPGC (0.011) were detected in this study. For the first time, 11 specimens harbouring the V410L mutation, and 8 samples with V1016I mutation were found. V410L and V1016I were coincided in 8 specimens. Also, six specimens contained 1016G/I double mutation which was not reported before. Conclusions: The relatively high frequency of these kdr mutations in Iranian Ae. aegypti indicates a population exhibiting substantial resistance to pyrethroid insecticides, which are used widely in control operations and household formulations. The detection of the 410L/1016I kdr mutant haplotype in Iranian Ae. aegypti suggests possible convergence of invasive populations from West Africa or Latin America. However, as Iran has very limited maritime/air connections with those African countries, a Latin American origin for the invasive Ae. aegypti in Iran is more plausible

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Impact of the Realistic Theories of International Relations on Development of International Law

The aim of this paper is to examine the impact of realistic theories of international relations on the development of international law. Realists, because of the anarchy in the international system, focus on power rather than the law. For this reason, they consider the relationship between power and law as a confrontational one. However, this research seeks to prove the hypothesis that power creates and advocates the rules of international law. Since the establishment of the sovereignty of nations, gradually rules to regulate the relations between States were developed. After that, the major powers took over the administration of international relations. History of international relations also shows that, in the period known as the hegemonic stability, although the hegemony benefited from the rules of international law in its own interests, it has acted as the main supporter of the rules of international law to maintain international stability and security. This paper, from a historical viewpoint, aims to examine the role of power in development of international law, by using a descriptive- analytic metho

Discourse Analysis in Schizophrenic Patients on the Basis of Grice\'s Cooperative Principles

Objective: The ultimate goal of this study is one of the discourse fields analysis, i.e. Grice's cooperative principles. Materials & Methods: In this comparative and case - control study, two groups of normal individuals and schizophrenic patients were selected by simple method from sample of convenience and interviewed based on the spontaneous part of Persian Aphasia Test. All the answers were analyzed with respect to the percent rate of errors in the 4 "cooperative maxims", and the errors were collected. Data were analyzed by Independent T Test, ANOVA, Kruskal Wallis and Mann Whitney. Results: There were significant differences between two groups in respect to all the Grice’s cooperative principles (P<0.001), maxim of quantity (P<0.001), maxim of relevance (P<0.001) and maxim of manner (P=0.02), but in maxim of quality there was no significant differeance (P=0.07). The mean percent of errors in the course of illness, education and age varieties were not significant. Conclusion: Schizophrenic patients have incoherence speech and this problem exists in the discourse field and social interactions, thus the patients frequently fail in observing the Gricean cooperative principles

A Novel Hybrid Backscatter and Conventional Algorithm for Multi-Hop IoT Networks

This paper investigates a multi-hop cognitive radio network in terms of end-to-end bit delivery. The network exploits backscatter communication (BackCom) and harvest-then-transmit (HTT) mode in a hybrid manner. Such a network can be used in internet of things (IoT) applications in which IoT users coexist with a primary network (PN) and use the primary spectrum to transmit data in both BackCom and HTT modes. Besides, such users can harvest energy from the primary signals. A novel hybrid backscatter and conventional transmission (HBCT) algorithm is proposed in order to maximize end-to-end bit delivery by jointly optimizing time and power allocations. For this goal, we formulate a non-convex optimization problem. Next, we transform the problem into a convex one and develop a new analytical formulation by which we calculate the optimal power and time allocation in closed-form equations. The numerical results demonstrate the superiority of HBCT compared with current schemes

Meta-evaluation of published studies on evaluation of health disaster preparedness exercises through a systematic review

Objective: Exercise evaluation is one of the most important steps and sometimes neglected in designing and taking exercises, in this stage of exercise, it systematically identifying, gathering, and interpreting related information to indicate how an exercise has fulfilled its objectives. The present study aimed to assess the most important evaluation techniques applied in evaluating health exercises for emergencies and disasters. Methods: This was meta-evaluation study through a systematic review. In this research, we searched papers based on specific and relevant keywords in research databases including ISI web of science, PubMed, Scopus, Science Direct, Ovid, ProQuest, Wiley, Google Scholar, and Persian database such as ISC and SID. The search keywords and strategies are followed; “simulation,” “practice,” “drill,” “exercise,” “instrument,” “tool,” “questionnaire,” “ measurement,” “checklist,” “scale,” “test,” “inventory,” “battery,” “evaluation,” “assessment,” “appraisal,” “emergency,” “disaster,” “cricise,” “hazard,” “catastrophe,: “hospital”, “prehospital,” “health centers,” “treatment centers,” were used in combination with Boolean operators OR and AND. Results: The research findings indicate that there are different techniques and methods for data collection to evaluate performance exercises of health centers and affiliated organizations in disasters and emergencies including debriefing inventories, self-report, questionnaire, interview, observation, shooting video, and photographing, electronic equipment which can be individually or collectively used depending on exercise objectives or purposes. Conclusion: Taking exercise in the health sector is one of the important steps in preparation and implementation of disaster risk management programs. This study can be thus utilized to improve preparedness of different sectors of health system according to the latest available evaluation techniques and methods for better implementation of disaster exercise evaluation stages